Updates
  • The International Journal of Biological Research (TIJOBR)- Published Quarterly
  • The International Journal of Global Sciences (TIJOGS) -Published Quarterly

Ameliorating hyperglycemia by Ananas comosus leaves extract


The International Journal of Biological Research (TIJOBR)

PDF

Muhammad Adeel1, Muhammad Awais Mansha1, Ali Asghar1, Atiq ur Rahman1, Muhammad Aqib Saeed1

1National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

*Corresponding author’s email: ch.awais3802@gmail.com  

Submitted Accepted Published
Oct 12,2019 Dec 18,2019 Jan 15,2020

2020 / Vol: 3 / Issue: 2


Abstract


Consumption of therapeutic and functional foods has been associated with health promotion and reduction in risk of diseases. Globally, almost 800 plants have been identified with their anti-diabetic and anti-hyperlipidemia therapeutic properties. Ananas comosus has gained much attention in terms of therapeutic effects including anti-diabetic, anti-oxidative, anti-diarrheal and anti-hyperlipidemia properties. Proposed study has been designed to explore the effect of A. comosus leaves extract on hyperglycemia and other blood parameters. Study was carried out on male rats. Twenty rats were equally distributed in 4 groups. Rats were provided with A. comosus leaves extract for 35 days. Serum samples were collected to check the level of serum glucose, glycosylated hemoglobin, AST, ALP, ALT, uric acid, urea and creatinine. Blood serum was be used to determine the level of uric acid, protein, urea and creatinine. Collected data of tests performed was statistically analyzed to check the significance level. Ananas comosus were used for proximate analysis. The results were statistically analyzed for the glucose levels, protein levels, HbA1c, urea uric acid, creatinine, uric acid, ALP, AST, ALT concentrations from the blood samples. Results indicated that A. comosus leaves have anti-diabetic properties and does not possess any harmful effect on kidney and liver. 

Key words: Ananas comosus, hyperglycemia, anti-hyperlipidemia properties


Reference


  1. Daher, C., J. Abou-Khalil and G. Baroody. 2005. Effect of acute and chronic grapefruit, orange and pineapple juice intake on blood lipid profile in normolipidemic rat. Medical Science Monitor. 11:465-472.
  2. Fossati N, Karnes RJ, Cozzarini C, et al: Assessing the optimal timing for early salvage radiation therapy in patients with prostate-specific antigen rise after radical prostatectomy. Eur Urol 69:728-733, 2016
  3. Hopkins, P.N., Heiss, G., Ellison, R.C., Province, M.A., Pankow, J.S., Eckfeldt, J.H. and Hunt, S.C., 2003. Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation, 108(5), pp.519-523.
  4. Joseph J.D., Lu N., Qian J., Sensintaffar J., Shao G., Brigham D., Moon M., Maneval E.C., Chen I., Darimont B., Hager J.H. A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509. Cancer Discov. 2013;3:1020–1029. 
  5. Kalpana, M.B., G.S. Prasath, and M .Subramanian, 2014. Studies on the antidiabetic activity of Ananas comosus leaves in STZ induced diabetic rats, Der Pharmacia Lettre., 6 (1):190-198.
  6. Ketnawa, S., P. Chaiwut, and S. Rawdkuen. 2012. Pineapple wastes: A potential source for bromelain extraction. Food and Bioproducts Processing. 90: 385-391. doi: 10.1016/j.fbp.2011.12.006.
  7. Muhammad Ali Hashmi, Afsar Khan, Muhammad Hanif, Umar Farooq, and Shagufta Perveen, “Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive),” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 541591, 29 pages, 2015. 
  8. Najafi B, Crews RT, Wrobel JS. Importance of time spent standing for those at risk of diabetic foot ulceration. Diabetes Care. 2010;33(11):2448–2450.
  9. Najafi B, Horn D, Marclay S, Crews RT, Wu S, Wrobel JS. Foot technology, part 1 of 2: assessing postural control and postural control strategy in diabetes patients using innovative and wearable technology. Journal of Diabetes Science and Technology. 2010;4(4):780–791.
  10. Nawaz, M.A., Ahmed, W., Maqbool, M., Saleem, B.A., Hussain, Z., Aziz, M. and Shafique, A., 2012. Characteristics of some potential cultivars for diversification of citrus industry of Pakistan. Int. J. Agric. Appl. Sci. Vol, 4(1).
  11. Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J. 2012;27(4):269–273. doi: 10.5001/omj.2012.68
  12. Ramahi TM, Khwaja M. , Abu-Rmeileh N. , Abdelrahim S. Socioeconomic disparities in heart disease in the Republic of Lebanon: findings from a population-based study. Heart Asia. In press. Date of acceptance: 10 Mar 2010, DOI number: 10.1136/ha.2009.000851.
  13. Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. African journal of traditional, complementary, and alternative medicines: AJTCAM, 8(5 Suppl), 208–213. doi:10.4314/ajtcam.v8i5S.9
  14. Sripanidkulchai. B, S. Na-nakorn, V. Wongpanich, P. Tanyakupta. A behavioral investigation on utilization of medicinal plants for dysuria at Pon District, Khon Kaen. Khon Kaen University Research Journal, vol. 5 (2000), pp. 4-10.
  15. Xie, W., Wang, W., Su, H., Xing, D., Cai, G. and Du, L., 2007. Hypolipidemic mechanisms of Ananascomosus L. leaves in mice: different from fibrates but similar to statins. Journal of pharmacological sciences, 103(3), pp.267-274.
  16. Xie, W., Xing, D., Sun, H., Wang, W., Ding, Y. and Du, L., 2005. The effects of Ananascomosus L. leaves on diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet. The American Journal of Chinese Medicine, 33(01), pp.95-105.


© Copy Rights
By Authors and RnD Journals.
http://rndjournals.com