The International Journal of Biological Research (TIJOBR)
Muhammad Saad Majeed1, Muhammad Inam ur Raheem1, Muhammad Awais Mansha1*,
Muhammad Adeel1, Muhammad Aqib Saeed1, Mehnaz Mushtaq1, Hassan Raza2
1National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.
2Department of food science and Technology, The Islamia University of Bahawalpur
*Corresponding author’s email: firstname.lastname@example.org
|Jul 11,2019||Oct 27,2019||Nov 06,2019|
2019 / Vol: 2 / Issue: 4
Worldwide, millions of people are suffering from chronic illnesses and health ailments including hypercholesterolemia and hyperglycemia. Current study was carried out to elucidate the comparative effect of Ananas comosus L. dried cuts (ADC) and leaf extract (ALE) on overall body weight, lipid profile and atherogenic indices (AI) in hypercholesterolemic rats. Phytochemical screening tests demonstrated that ALE exhibited far better results against total phenolic content and DPPH assay as compared with ADC. In efficacy study, moderate and higher doses of ADC (6% and 9%) and ALE (0.6 gm/Kg and 0.9 gm/Kg) were administered to hypercholesterolemic rats for 40 days. Concluded results were analyzed statistically and compared with normal and hypercholesterolemic rats group. Significant reduction in overall body weight gain percentage, feed efficiency ratio, TC, LDL-c, VLDL-c, TG, organs weight (liver and kidney), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and AI was observed with the exception of HDL-c that increased significantly after applying ADC and ALE treatments solely in hypercholesterolemic rats in comparison to control (hypercholesterolemic) group. Since ALE possess TPC and antioxidant load higher than ADC so consequently lipid metabolizing activity of ALE was seen to be higher than that of ADC. Both treatments of ALE revealed even better results in reducing plasma lipid level, overall body weight gain and atherogenicity risks factors as compared with ADC (6% and 9%) treatments. Hence, it may be concluded that ALE treatments seemed to be more efficient in controlling and managing hypercholesterolemia without affecting vital organs or causing any toxicity issues in hypercholesterolemic rats.Key words: Ananas comosus L, atherogenic indices, efficacy study, hypercholesterolemia, hyperlipidemia.
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