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Effect of Ananas comosus L. Dried Cuts and Leave Extract on hypercholesterolemic Rats


The International Journal of Biological Research (TIJOBR)

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Muhammad Saad Majeed1, Muhammad Inam ur Raheem1, Muhammad Awais Mansha1*

Muhammad Adeel1, Muhammad Aqib Saeed1, Mehnaz Mushtaq1, Hassan Raza2

1National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

2Department of food science and Technology, The Islamia University of Bahawalpur

*Corresponding author’s email: ch.awais3802@gmail.com

Submitted Accepted Published
Jul 11,2019 Oct 27,2019 Nov 06,2019

2019 / Vol: 2 / Issue: 4


Abstract


Worldwide, millions of people are suffering from chronic illnesses and health ailments including hypercholesterolemia and hyperglycemia. Current study was carried out to elucidate the comparative effect of Ananas comosus L. dried cuts (ADC) and leaf extract (ALE) on overall body weight, lipid profile and atherogenic indices (AI) in hypercholesterolemic rats. Phytochemical screening tests demonstrated that ALE exhibited far better results against total phenolic content and DPPH assay as compared with ADC. In efficacy study, moderate and higher doses of ADC (6% and 9%) and ALE (0.6 gm/Kg and 0.9 gm/Kg) were administered to hypercholesterolemic rats for 40 days. Concluded results were analyzed statistically and compared with normal and hypercholesterolemic rats group. Significant reduction in overall body weight gain percentage, feed efficiency ratio, TC, LDL-c, VLDL-c, TG, organs weight (liver and kidney), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and AI was observed with the exception of HDL-c that increased significantly after applying ADC and ALE treatments solely in hypercholesterolemic rats in comparison to control (hypercholesterolemic) group. Since ALE possess TPC and antioxidant load higher than ADC so consequently lipid metabolizing activity of ALE was seen to be higher than that of ADC. Both treatments of ALE revealed even better results in reducing plasma lipid level, overall body weight gain and atherogenicity risks factors as compared with ADC (6% and 9%) treatments. Hence, it may be concluded that ALE treatments seemed to be more efficient in controlling and managing hypercholesterolemia without affecting vital organs or causing any toxicity issues in hypercholesterolemic rats.

Key words: Ananas comosus L, atherogenic indices, efficacy study, hypercholesterolemia, hyperlipidemia.



Reference


  1. Abid, N., Khan, S.A. and Taseer, I.H., 2012. Frequency of Hyperlipidemia in Patients Presenting with Ischemic Stroke. Pak J Med Health Sci Apr-Jun, 6(2), pp.423-7.
  2. Adeyemi,O.T., O.Osilesi, O.O. Adebawo, F.D. Onajobi and S.O. Oyedemi. 2015. Growth Performance of Weaned Male Albino Rats Fed on Processed Atlantic Horse Mackerel (Trachurustrachurus). Advances in Life Science and Technology. 30:53-61.
  3. Ajani, R.A., Adeniran, M.K., Olabinri, B.M. and Ajani, A.J., 2012. In-Vivo Assessment of Some Haematological and Biochemical Parameters in Normal Wistar Rats Treated with Pineapple (AnanasComosus) Wine. American International Journal of Contemporary Research, 2(11), pp.141-146.
  4. Ajiboso, S.O. Musa T Yakubu. Adenike T Oladiji. Evaluation of Anti-hyperlipidemic Potential of Aqueous Extract of Calotropis procera Leaf in Alloxan-Induced Diabetic Rat.2016, 3(2):161-167.
  5. Al-Hamedan, W.A., 2010. Protective effect of Lepidium sativum L. seeds powder and extract on hypercholesterolemic rats. Journal of American Science, 6(11), pp.873-879.
  6. AL-Sowyan, N.S., 2009. Difference in leptin hormone response to nutritional status in normal adult male albino rats. Pakistan Journal of Biological Sciences, 12(2), p.119-126.
  7. Bartholomew, D.P., Paull, R.E. and Rohrbach, K.G. eds., 2002. The pineapple: botany, production, and uses. CABI.
  8. Bahnasy, R.M. and E.M. Yassin. 2015. Effect of pumpkin (Cucurbita moschata) and pineapple (Ananas comosus L.) on obese hyperlipidemic rats. Academic Journal of Nutrition. 4:90-98.
  9. Bhatnagar, D., Soran, H. and Durrington, P.N. 2008. Hypercholesterolaemia and its management. Bmj, 337, p.a993.
  10. Daher, C., J. Abou-Khalil and G. Baroody. 2005. Effect of acute and chronic grapefruit, orange and pineapple juice intake on blood lipid profile in normolipidemic rat. Medical Science Monitor. 11:465-472.
  11. Hale, L.P., Greer, P.K., Trinh, C.T. and Gottfried, M.R. 2005. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clinical Immunology, 116(2), pp.135-142.
  12. Hijazi, M.A., A.A. Alrasheedi and L.M. Saeed. 2016. Effect of pineapple leaves extract (PLE) on lipid profile, glucose, insulin concentration and atherogenic index in hypercholesterolemic rats. Middle East Journal of Applied Sciences. 6:824-832.
  13. Hopkins, P.N., Heiss, G., Ellison, R.C., Province, M.A., Pankow, J.S., Eckfeldt, J.H. and Hunt, S.C., 2003. Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study. Circulation, 108(5), pp.519-523.
  14. Islam, M.M., M. Mahabub-Uz-Zaman, R. Aktar and N.U. Ahmed. 2011. Hypocholesterolemic effect of ethanol extract of Ananas comosas (L.) Merr. leaves in high cholesterol fed albino rats. International Journal of Life Sciences. 5:57-62
  15. Jafar, T.H., Chaturvedi, N. and Pappas, G., 2006. Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian population. Canadian Medical Association Journal, 175(9), pp.1071-1077.
  16. Kanthe, P.S., Patil, B.S., Bagali, S., Deshpande, A., Shaikh, G.B. and Aithala, M., 2012. Atherogenic index as a predictor of cardiovascular risk among women with different grades of obesity. International Journal of Collaborative Research on Internal Medicine & Public Health, 4(10), p.1767.
  17. Kemasari, P., Sangeetha, S. and Venkatalakshmi, P., 2011. Antihyperglycemic activity of Mangiferaindica Linn. in alloxan induced diabetic rats. J Chem Pharm Res, 3(5), pp.653-9.
  18. Ketnawa, S., Chaiwut, P. and Rawdkuen, S., 2012. Pineapple wastes: a potential source for bromelain extraction. Food and bioproducts processing, 90(3), pp.385-391.
  19. Li, T., Shen, P., Liu, W., Liu, C., Liang, R., Yan, N. and Chen, J., 2014. Major polyphenolics in pineapple peels and their antioxidant interactions. International journal of food properties, 17(8), pp.1805-1817.
  20. Lu, X.H., D.Q. Sun, Q.S. Wu, S.H. Liu and G.M. Sun. 2014. Physico-chemical properties, antioxidant activity and mineral contents of pineapple genotypes grown in China. Molecules. 19:8518-8532.
  21. Matos, S.L., Paula, H.D., Pedrosa, M.L., Santos, R.C.D., Oliveira, E.L.D., Chianca Júnior, D.A. and Silva, M.E., 2005. Dietary models for inducing hypercholesterolemia in rats. Brazilian Archives of Biology and Technology, 48(2), pp.203-209.
  22. Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P.K. and Lal, J., 2005. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. Journal of ethnopharmacology, 97(3), pp.497-501.
  23. Musial, D.C., Ostrowski, A.P., Ostrowski, M., Bracht, L. and Broetto-Biazon, A.C., 2015. Comparative study of hypocholesterolemic potential of pineapple and passion fruit peels in rats and mice. RevistaBrasileira de Pesquisaem Alimentos v, 6(1), pp.64-69.
  24. Nawaz, M.A., Ahmed, W., Maqbool, M., Saleem, B.A., Hussain, Z., Aziz, M. and Shafique, A., 2012. Characteristics of some potential cultivars for diversification of citrus industry of Pakistan. Int. J. Agric. Appl. Sci. Vol, 4(1).
  25. Ramallo, L.A. and Mascheroni, R.H., 2012. Quality evaluation of pineapple fruit during drying process. Food and bioproducts processing, 90(2), pp.275-283.
  26. Rathod, N.R., Raghuveer, I., Chitme, H.R. and Chandra, R., 2009. Free radical scavenging activity of Calotropis gigantea on streptozotocin-induced diabetic rats. Indian journal of pharmaceutical sciences, 71(6), p.615.
  27. Saeed, L.M., Hijazi, M.A. and Alrasheedi, A.A., 2016. Effect of Pineapple Leaves Extract (PLE) on Body Weight Gain and Histopathological Changes in Liver of Hypercholesterolemic Rats. 5:448-458. 
  28. Sripanidkulchai, B., Na-nakorn, S., Wongpanich, V. and Tanyakupta, P., 2000. Behavioral investigation on utilization of medicinal plants for dysuria at Pon District, KhonKaen. WarasanWichai Mo-Kho.
  29. Stapleton, P.A., Goodwill, A.G., James, M.E., Brock, R.W. and Frisbee, J.C., 2010. Hypercholesterolemia and microvascular dysfunction: interventional strategies. Journal of inflammation, 7(1), p.54.
  30. Vuyyuru, A., S. Kotagiri, V. Swamy and A. Swamy. 2012. Antihyperlipidemic activity of Ananascomosus L. leaves extract in albino rats. ResearchJournal of Pharmaceutical, Biological and Chemical Sciences. 3:1229-1242.
  31. Xie, W., Xing, D., Sun, H., Wang, W., Ding, Y. and Du, L., 2005. The effects of Ananascomosus L. leaves on diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet. The American Journal of Chinese Medicine, 33(01), pp.95-105.
  32. Xie, W., Wang, W., Su, H., Xing, D., Cai, G. and Du, L., 2007. Hypolipidemic mechanisms of Ananascomosus L. leaves in mice: different from fibrates but similar to statins. Journal of pharmacological sciences, 103(3), pp.267-274.
  33. Xie, W., Zhang, S., Lei, F., Ouyang, X. and Du, L., 2014. Ananascomosus L. Leaf phenols and p-coumaric acid regulate liver fat metabolism by upregulating CPT-1 expression. Evidence-Based Complementary and Alternative Medicine, 2014.
  34. Yuris, A. and Siow, L.F., 2014. A comparative study of the antioxidant properties of three pineapple (Ananascomosus L.) varieties. Journal of Food Studies, 3(1), pp.40-56.


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