• The International Journal of Biological Research (TIJOBR)- Published Quarterly
  • The International Journal of Global Sciences (TIJOGS) -Published Quarterly

Effects of omega 3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the Alzheimer’s disease and depression treatment

The International Journal of Biological Research (TIJOBR)


Zain-Ul-Abedin1*, Amina Jamil1, Muhammad Fahad Latif1, Ali Raza1, Neelum Shahzadi1, Sana Mehmood1, Yasmeen Bano2

1National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

2National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Sub campus Burewala, Vehari, Pakistan.

*Corresponding author’s email: zaing0092@gmail.com 

Submitted Accepted Published
Jun 05,2019 Aug 21,2019 Sep 29,2019

2019 / Vol: 2 / Issue: 3


Omega 3 polyunsaturated fatty acids particularly EPA and DHA can prevent the diseases of brain related disorders at clinical as well as in experimental studies. These polyunsaturated fatty acids improve the brain health by the modulation of apoptotic pathways. EPA and DHA proved to be beneficial in Alzheimer’s by increasing the regulation of gene expression related with neurotransmission. It is also still unknown that whether EPA acts directly or as a precursor of DHA. Here we describe the role of EPA and DHA in the treatment of Alzheimer’s disease and depression as well as their beneficial role in the diabetes, inflammation, hearth heath and neurons related processes in the brain. The further analysis will show the beneficial and protective role of EPA and DHA that how they can combat and prevent these diseases. The omega 3 polyunsaturated fatty acids EPA and DHA have various properties of neuroprotection due to which these fatty acids proved to be beneficial and effective in the treatment of Alzheimer’s disease and depression. The patients of Alzheimer’s disease have lower levels of DHA in their brain; it can be reduced by the regular consumption of DHA supplementation. This review analyzes the hypothesis of EPA and DHA as effective components of PUFA in the treatment of Alzheimer’s disease and depression. The consumption of long chain omega 3 polyunsaturated fatty acids EPA and DHA found in the fish oils show the beneficial effects on the neuropsychiatric diseases. 

Keywords: Alzheimer’s, depression, EPA, DHA


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